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A crystal structure of PIM-1 is described that was determined by X-ray crystallography. The use of PIM-1 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PIM- 1 and ...

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WO2011160126A2 - S-adenosyl-(l)-homocysteine (sah) riboswitches and compositions and uses thereof - Google Paten

Metabolites bearing an adenine ring, including ATP, bind this aptamer with sufficiently high affinity such that normal intracellular concentrations of these compounds may influence regulation of the riboswitch. ...